Successful treatment of empyema thoracis with human recombinant deoxyribonuclease.
نویسندگان
چکیده
Fibrinolytic enzymes, particularly streptokinase, are now widely used to treat empyema thoracis. Recent in vitro evidence suggests that streptokinase has no effect on pus viscosity but that deoxyribonuclease (DNase) reduces the viscosity of pus. We report the first use of human recombinant DNase given intrapleurally to treat an empyema which had not resolved after standard treatment with streptokinase.
منابع مشابه
Neonatal Empyema Thoracis: a case report
A term newborn was admitted to the neonatal intensive care unit immediately after the birth, with respiratory distress due to congenital pneumonia. With progression of respiratory symptoms, empyema thoracis was diagnosed due to the right massive purulent pleural effusion in chest X ray. Treatment was fulfilled by ventilator support and pus drainage by means of two chest tubes and appropriate an...
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STUDY OBJECTIVE To investigate the effects of streptokinase and deoxyribonuclease (DNase) on the viscosity of pus to assess whether the DNase in the old preparation of streptokinase-streptodornase used intrapleurally to treat empyema was contributing to easier drainage of pus compared with purified streptokinase. DESIGN In vitro measurement of pus viscosity. PATIENTS Pus from three patients...
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BACKGROUND Empyema thoracis in children causes significant morbidity. Standard treatment of Empyema thoracis includes tube drainage and antibiotics. But the tube drainage often fails. Intrapleural Streptokinase has been used in empyema thoracis with good success rate. OBJECTIVES We evaluated the efficacy of intra-pleural Streptokinase in management of empyema thoracis even in advanced stages....
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ورودعنوان ژورنال:
- Thorax
دوره 58 4 شماره
صفحات -
تاریخ انتشار 2003